Component-Resolved Diagnostics
Advanced testing that identifies specific allergen components for precise risk assessment.
Overview
Component-resolved diagnostics (CRD) identifies specific proteins within allergens, allowing for more precise allergy diagnosis and risk assessment, particularly for food allergies.
peanut
components
ara H1
Storage protein - associated with more severe reactions
ara H2
Most important marker - high levels suggest higher risk
ara H3
Storage protein - similar to araH1
ara H8
Pollen-related - often indicates mild or oral allergy syndrome
ara H9
Lipid transfer protein - may indicate more severe reactions
interpretation
- High araH2: Higher risk of severe reactions, strict avoidance needed
- High araH8 only: May tolerate peanut, consider oral food challenge
- Multiple storage proteins: Higher risk profile
tree Nut
components
Similar component testing available for various tree nuts
uses
Helps determine risk and whether oral food challenge is appropriate
risk Stratification
high
- High levels of storage proteins (e.g., araH2 for peanut)
- Multiple component sensitization
- History of severe reactions
- Strict avoidance recommended
moderate
- Moderate component levels
- May need oral food challenge to determine tolerance
- Careful monitoring if challenge is performed
low
- Low levels or pollen-related components only
- May indicate tolerance or mild reactions
- Oral food challenge may be appropriate
- May only need to avoid raw form
uses
food
- Peanut and tree nut allergies
- Determining if oral food challenge is safe
- Predicting risk of severe reactions
- Identifying cross-reactivity patterns
other
Can be applied to other allergens as testing becomes available
benefits
- More precise than standard IgE testing
- Helps determine if oral food challenge is appropriate
- Can reduce unnecessary food avoidance
- Better risk assessment for severe reactions
limitations
- Not available for all allergens
- More expensive than standard testing
- Results must be interpreted by experienced allergist
- Doesn't replace clinical history
Ready to Get Started?
Schedule a consultation to discuss your specific needs and create a personalized treatment plan.