Oral Antihistamines · Second-generation oral antihistamine
Fexofenadine (Allegra): Generic Non-Drowsy Allergy Relief
Brand names: Allegra
Last reviewed June 8, 2026 · Medically reviewed by AllergyCenter
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Generic Fexofenadine 180 mg — 30 tablets
30 tablets (1-month supply)
- Same active ingredient as the brand
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For prescription strengths, combination products, or higher doses.
- Switch to cetirizine, levocetirizine, or hydroxyzine for stronger symptom control
- Add a nasal spray (Flonase, Astepro, Dymista) for nasal symptoms
- Build a combination plan for moderate-to-severe allergies
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Fexofenadine — sold OTC as Allegra — is a non-drowsy daily antihistamine for allergic rhinitis and hives. It's widely considered the least sedating of the common OTC antihistamines, which makes it a good choice for people who drive, operate machinery, or are sensitive to drowsiness from other allergy pills.
Standard adult dose is 180 mg once daily. Generic fexofenadine is identical to brand-name Allegra.
Quick Facts
- Generic name
- Fexofenadine hydrochloride
- Brand names
- Allegra, Allegra-D (with pseudoephedrine)
- Drug class
- Second-generation H1 antihistamine
- Form
- Tablet, dissolving tablet, liquid
- OTC or Rx
- OTC
- Typical adult dose
- 180 mg once daily (or 60 mg twice daily)
- Age range
- 2+ (dose by age; 180 mg form is 12+)
- Onset of action
- 1–2 hours
- Note
- Take on an empty stomach — fruit juice can reduce absorption
TL;DR — At a Glance
- ·Fexofenadine (Allegra) is a non-drowsy 24-hour antihistamine.
- ·Standard adult dose: 180 mg once daily.
- ·Least likely of the OTC antihistamines to cause drowsiness.
- ·Take on an empty stomach — fruit juice (apple, orange, grapefruit) can reduce how much your body absorbs.
- ·Common side effects: headache, mild stomach upset.
Symptoms not controlled on fexofenadine?
An allergist can review your symptoms, switch you to a different antihistamine, or build a combination plan with a nasal spray or eye drops.
Medical Disclaimer: This guide is for educational purposes only and is not a substitute for medical advice, diagnosis, or treatment from a licensed healthcare provider. Do not start, stop, or change any medication without consulting a qualified provider.